Pathophysiology of Disease: An Introduction to Clinical Medicine

The aim of this book is to provide students with an introduction to clinical medicine through the study of diseases as manifestations of pathophysiology. The authors (all experts in their respective fields) have provided a brief review of the relevant normal structure and function of each system in the body, followed by a description of the underlying pathophysiologic mechanisms that underlie several common diseases related to that system. With this approach comes an explication of the symptoms and signs of each disease state and an essential framework for the student’s later mastery of treatment strategies. Several subject areas that are not restricted to a single body system are also covered (eg, neoplasia and infectious disease), but the same approach is used in these instances as well. For the most part, diagnosis and treatment are not covered here but are left for later, more detailed study and textbooks such as the annually updated Current Medical Diagnosis & Treatment. No attempt is made here to be comprehensive or complete; the pathophysiology section of each chapter discusses one to five relevant clinical entities, based either on their frequency (eg, coronary artery disease and hypertension) or on their importance to understanding how physiologic systems may become disordered (eg, fragile X mental retardation or pheochromocytoma). The aim is to introduce students to diseases as manifestations of disordered function and to start them thinking about the related symptoms and signs in terms

  Contents:

1: Introduction

• 2: Genetic Disease
• 3: Disorders of the Immune System
• 4: Infectious Diseases
• 5: Neoplasia
• 6: Blood Disorders
• 7: Nervous System Disorders
• 8: Diseases of the Skin
• 9: Pulmonary Disease
• 10: Cardiovascular Disorders: Heart Disease
• 11: Cardiovascular Disorders: Vascular Disease
• 12: Disorders of the Adrenal Medulla
• 13: Gastrointestinal Disease
• 14: Liver Disease
• 15: Disorders of the Exocrine Pancreas
• 16: Renal Disease
• 17: Disorders of the Parathyroids & Calcium & Phosphorus Metabolism
• 18: Disorders of the Endocrine Pancreas
• 19: Disorders of the Hypothalamus & Pituitary Gland
• 20: Thyroid Disease
• 21: Disorders of the Adrenal Cortex
• 22: Disorders of the Female Reproductive Tract
• 23: Disorders of the Male Reproductive Tract
• 24: Inflammatory Rheumatic Diseases
• 25: Case Study Answers
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